abstract：:Relationships based on the microdosimetric-kinetic model are presented that calculate the average number of lethal lesions, and the associated cell survival, produced in mammalian cells by exposure to protracted continuous irradiation by temporary and permanent implantation of radioactive sources. The influence of cel...

journal_title：Radiation research

authors： Hawkins RB,Inaniwa T

更新日期：2014-07-01 00:00:00

abstract：:Radiation exposure causes DNA breaks leading to structural chromosome aberrations that can be carcinogenic. Lifetime cancer risks are elevated in irradiated children compared to similarly exposed adults. To determine the extent to which age influences the frequency and types of chromosome damage in response to ionizin...

journal_title：Radiation research

authors： Bakhmutsky MV,Joiner MC,Jones TB,Tucker JD

更新日期：2014-06-01 00:00:00

abstract：:A novel technique has been employed to investigate the simultaneous damage to DNA components induced by soft X rays (1.5 keV) and low-energy electrons (0-30 eV) in thin films of thymidine deposited on glass and tantalum substrates and irradiated under atmospheric pressure and temperature. The films were surrounded by ...

journal_title：Radiation research

authors： Alizadeh E,Sanz AG,Madugundu GS,García G,Wagner JR,Sanche L

更新日期：2014-06-01 00:00:00

abstract：:The radiation risk of skin cancer by histological types has been evaluated in the atomic bomb survivors. We examined 80,158 of the 120,321 cohort members who had their radiation dose estimated by the latest dosimetry system (DS02). Potential skin tumors diagnosed from 1958 to 1996 were reviewed by a panel of pathologi...

journal_title：Radiation research

authors： Sugiyama H,Misumi M,Kishikawa M,Iseki M,Yonehara S,Hayashi T,Soda M,Tokuoka S,Shimizu Y,Sakata R,Grant EJ,Kasagi F,Mabuchi K,Suyama A,Ozasa K

更新日期：2014-05-01 00:00:00

abstract：:In this study, we investigated the effect of (131)I gelatin microspheres ((131)I-GMSs) on human hepatocellular carcinoma cells (HepG2) in nude mice (Balb/c) and the biodistribution of (131)I-GMSs after intratumoral injection. The treatment group and control group animals received intratumoral injections of 1 mCi (131)...

journal_title：Radiation research

authors： Chi JL,Li CC,Xia CQ,Li L,Ma Y,Li JH,Chen Z,Chen XL

更新日期：2014-04-01 00:00:00

abstract：:Radiation therapy for the treatment of thoracic cancers may be associated with radiation-induced heart disease (RIHD), especially in long-term cancer survivors. Mechanisms by which radiation causes heart disease are largely unknown. To identify potential long-term contributions of mitochondria in the development of ra...

journal_title：Radiation research

authors： Sridharan V,Aykin-Burns N,Tripathi P,Krager KJ,Sharma SK,Moros EG,Corry PM,Nowak G,Hauer-Jensen M,Boerma M

更新日期：2014-03-01 00:00:00

abstract：:Polonium-210 is a naturally occurring radioactive element that decays by emitting an alpha particle. It is in the air we breathe and also a component of tobacco smoke. Polonium-210 is used as an anti-static device in printing presses and gained widespread notoriety in 2006 after the poisoning and subsequent death of a...

journal_title：Radiation research

authors： Boice JD Jr,Cohen SS,Mumma MT,Ellis ED,Cragle DL,Eckerman KF,Wallace PW,Chadda B,Sonderman JS,Wiggs LD,Richter BS,Leggett RW

更新日期：2014-02-01 00:00:00

abstract：:At the outset of the accident at Fukushima Daiichi Nuclear Power Plant in March 2011, the radiation doses experienced by residents were calculated from the readings at monitoring posts, with several assumptions being made from the point of view of protection and safety. However, health effects should also be estimated...

journal_title：Radiation research

authors： Nagataki S,Takamura N,Kamiya K,Akashi M

更新日期：2013-11-01 00:00:00

abstract：:This study demonstrates that mice, similar to humans, have a common mitochondrial DNA deletion (3,860 bp) that encodes 5 transfer RNA genes and 5 polypeptide genes that is related to aging, tissue type and radiotoxicity. Our research indicates that the deletion ratio in the liver was significantly higher than in the b...

journal_title：Radiation research

authors： Zhang SB,Maguire D,Zhang M,Zhang Z,Zhang A,Yin L,Zhang L,Huang L,Vidyasagar S,Swarts S,Okunieff P

更新日期：2013-10-01 00:00:00

abstract：:The effect of transgenerational exposure to low dose rate (2.4 and 21 mGy/day) gamma irradiation on the yield of DNA double-strand breaks and oxidized guanine (8-hydroxyguanine) has been studied in the muscle and liver tissue of a model organism, the Japanese medaka fish. We found the level of unrepaired 8-hydroxyguan...

journal_title：Radiation research

authors： Grygoryev D,Moskalenko O,Hinton TG,Zimbrick JD

更新日期：2013-09-01 00:00:00

abstract：:The possibility of a large-scale acute radiation exposure necessitates the development of new methods that could provide rapid individual dose estimates with high sample throughput. The focus of the study was an intercomparison of laboratories' dose-assessment performances using gene expression assays. Lithium-heparin...

journal_title：Radiation research

authors： Badie C,Kabacik S,Balagurunathan Y,Bernard N,Brengues M,Faggioni G,Greither R,Lista F,Peinnequin A,Poyot T,Herodin F,Missel A,Terbrueggen B,Zenhausern F,Rothkamm K,Meineke V,Braselmann H,Beinke C,Abend M

更新日期：2013-08-01 00:00:00

abstract：:The study design and obtained results represent an intercomparison of various laboratories performing dose assessment using the dicentric chromosome analysis (DCA) as a diagnostic triage tool for individual radiation dose assessment. Homogenously X-irradiated (240 kVp, 1 Gy/min) blood samples for establishing calibrat...

journal_title：Radiation research

authors： Beinke C,Barnard S,Boulay-Greene H,De Amicis A,De Sanctis S,Herodin F,Jones A,Kulka U,Lista F,Lloyd D,Martigne P,Moquet J,Oestreicher U,Romm H,Rothkamm K,Valente M,Meineke V,Braselmann H,Abend M

更新日期：2013-08-01 00:00:00

abstract：:We have investigated how radiation quality affects the induction of chromosomal aberrations in human cells. Human lymphocytes were irradiated in vitro with various energies of accelerated high charge and energy (HZE) particles including oxygen, neon, silicon, titanium and iron. Chromosome damage was assessed using thr...

journal_title：Radiation research

authors： George KA,Hada M,Chappell L,Cucinotta FA

更新日期：2013-07-01 00:00:00

abstract：:Information on early internal radiation doses in Fukushima after the nuclear power plant accident on March 11, 2011, is quite limited due to initial organizational difficulties, high background radiation and contamination of radiation measuring devices. In Nagasaki, approximately 1,200 km away from Fukushima, the inte...

journal_title：Radiation research

authors： Matsuda N,Kumagai A,Ohtsuru A,Morita N,Miura M,Yoshida M,Kudo T,Takamura N,Yamashita S

更新日期：2013-06-01 00:00:00

abstract：:While lifespan studies provide basic information for estimating the risk of ionizing radiation, findings on the effect of low-dose/low-dose-rate irradiation on the lifespan of mammals are controversial. Here we evaluate the effect of continuous exposure to low-dose-rate γ radiation on the lifespan of mice with acceler...

journal_title：Radiation research

authors： Nomura T,Sakai K,Ogata H,Magae J

更新日期：2013-06-01 00:00:00

abstract：:Neurons are essential components of neural circuits and provide brain function organization. We previously reported that X irradiation induces apoptosis in immature neurons. To the best of our knowledge, there have been few reports investigating the effects of X irradiation on mature neurons. We analyzed the effects o...

journal_title：Radiation research

authors： Shirai K,Mizui T,Suzuki Y,Okamoto M,Hanamura K,Yoshida Y,Hino M,Noda SE,Al-jahdari WS,Chakravarti A,Shirao T,Nakano T

更新日期：2013-06-01 00:00:00

abstract：:Proton exposure induces mutations and cancer, which are presumably linked. Because protons are abundant in the space environment and significant uncertainties exist for the effects of space travel on human health, the purpose of this study was to identify the types of mutations induced by exposure of mammalian cells t...

journal_title：Radiation research

authors： Turker MS,Grygoryev D,Dan C,Eckelmann B,Lasarev M,Gauny S,Kwoh E,Kronenberg A

更新日期：2013-05-01 00:00:00

abstract：:Previously, we described the radiation-induced (RI) 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) effect as the increased MTT metabolization at the intermediate dose region after the irradiation of an MCF-7/6 cell monolayer with an X-ray dose gradient. We wondered if the cell monolayer at the inte...

journal_title：Radiation research

authors： Blockhuys S,Vanhoecke B,Smet J,De Paepe B,Van Coster R,Bracke M,De Wagter C

更新日期：2013-04-01 00:00:00

abstract：:An understanding of proton radiobiology is critical for optimization of both proton radiotherapy and assessment of carcinogenesis risk from space radiation. Although the physical aspects of proton beam radiobiology is well understood, the biological aspects, particularly the complex biological end points, have been un...

journal_title：Radiation research

authors： Girdhani S,Sachs R,Hlatky L

更新日期：2013-03-01 00:00:00

abstract：:In this study, we investigated the accuracy of using off-line bioluminescence imaging (BLI) and tomography (BLT) to guide irradiation of small soft tissue targets on a small animal radiation research platform (SARRP) with on-board cone beam CT (CBCT) capability. A small glass bulb containing BL cells was implanted as ...

journal_title：Radiation research

authors： Tuli R,Armour M,Surmak A,Reyes J,Iordachita I,Patterson M,Wong J

更新日期：2013-02-22 00:00:00

abstract：:Very low doses of ionizing radiation, 5 to 100 mGy, can induce adaptive responses characterized by elevation in cell survival and reduction in micronuclei formation. Utilizing these end points, RKO human colon carcinoma and transformed mouse embryo fibroblasts (MEF), wild-type or knockout cells missing TNF receptors 1...

journal_title：Radiation research

authors： Grdina DJ,Murley JS,Miller RC,Mauceri HJ,Sutton HG,Thirman MJ,Li JJ,Woloschak GE,Weichselbaum RR

更新日期：2013-02-01 00:00:00

abstract：:A radiation-induced bystander response, which is generally defined as a cellular response that is induced in nonirradiated cells that received bystander signals from directly irradiated cells within an irradiated cell population. In our earlier X-ray microbeam studies, bystander cell killing in normal human fibroblast...

journal_title：Radiation research

authors： Tomita M,Maeda M,Kobayashi K,Matsumoto H

更新日期：2013-02-01 00:00:00

abstract：:Aberrant expression of microRNAs (miRNAs) is frequently associated with a variety of cancers, including breast cancer. We and others have demonstrated that radiation-induced rat mammary cancer exhibits a characteristic gene expression profile and a random increase in aberrant DNA copy number; however, the role of aber...

journal_title：Radiation research

authors： Iizuka D,Imaoka T,Nishimura M,Kawai H,Suzuki F,Shimada Y

更新日期：2013-02-01 00:00:00

abstract：:Alteration of adhesion molecule expression on endothelial cells has a direct connection with ionizing radiation-induced atherosclerosis, which is an adverse effect observed after radiotherapy. However, minimal attention has been given to monocytes/macrophages role in atherosclerosis development, which are exposed to t...

journal_title：Radiation research

authors： Yuan Y,Lee SH,Wu S

更新日期：2013-01-01 00:00:00

abstract：:Cytokines function in many roles that are highly relevant to radiation research. This review focuses on how cytokines are structurally organized, how they are induced by radiation, and how they orchestrate mesenchymal, epithelial and immune cell interactions in irradiated tissues. Pro-inflammatory cytokines are the ...

journal_title：Radiation research

authors： Schaue D,Kachikwu EL,McBride WH

更新日期：2012-12-01 00:00:00

abstract：:It is commonly accepted that ionizing radiation induces genomic instability by changes in genomic structure, epigenetic regulation and gene expression. Human endogenous retroviruses (HERV)-R also are often differentially expressed between normal and disease tissues under unstable genomic conditions and are implicated ...

journal_title：Radiation research

authors： Lee JR,Ahn K,Kim YJ,Jung YD,Kim HS

更新日期：2012-11-01 00:00:00

abstract：:While the risk of lung cancer associated separately with smoking and radiation exposure has been widely reported, it is not clear how smoking and radiation together contribute to the risk of specific lung cancer histological types. With individual smoking histories and radiation dose estimates, we characterized the jo...

journal_title：Radiation research

authors： Egawa H,Furukawa K,Preston D,Funamoto S,Yonehara S,Matsuo T,Tokuoka S,Suyama A,Ozasa K,Kodama K,Mabuchi K

更新日期：2012-09-01 00:00:00

abstract：:Cell-cell contact is thought to be critically involved in mechanisms leading to radioresistance. Here, we assessed the influence of confluent compared to subconfluent cell culture conditions and the radiosensitizing ability of E-cadherin inhibition alone or in combination with C225-mediated EGFR inhibition in human sq...

journal_title：Radiation research

authors： Mazzeo E,Hehlgans S,Valentini V,Baumann M,Cordes N

更新日期：2012-09-01 00:00:00

abstract：:Currently, there is a serious absence of pharmaceutically attractive small molecules that mitigate the lethal effects of an accidental or intentional public exposure to toxic doses of ionizing radiation. Moreover, cellular systems that emulate the radiobiologically relevant cell populations and that are suitable for h...

journal_title：Radiation research

authors： Zellefrow CD,Sharlow ER,Epperly MW,Reese CE,Shun T,Lira A,Greenberger JS,Lazo JS

更新日期：2012-09-01 00:00:00

abstract：:Radiation-induced heart disease (RIHD) is a serious side effect of radiotherapy for intrathoracic and chest wall tumors. The threshold dose for development of clinically significant RIHD is believed to be lower than previously assumed. Therefore, research into mechanisms of RIHD has gained substantial momentum. RIHD b...

journal_title：Radiation research

authors： Boerma M

更新日期：2012-07-01 00:00:00

abstract：:Transforming growth factor-β-activated kinase 1 (TAK1) appears to play a role in inhibiting apoptotic death in response to multiple stresses. To assess the role of TAK1 in X-ray induced apoptosis and cell death, we irradiated parental and siRNA-TAK1-knockdown HeLa cells. Changes in gene expression levels with and with...

journal_title：Radiation research

authors： Furusawa Y,Wei ZL,Sakurai H,Tabuchi Y,Li P,Zhao QL,Nomura T,Saiki I,Kondo T

更新日期：2012-06-01 00:00:00

abstract：:There is growing scientific, regulatory and public concern over anthropogenic input of radionuclides to the aquatic environment, especially given the issues surrounding existing nuclear waste, future energy demand and past or potential nuclear accidents. A change in the approach to how we protect the environment from ...

journal_title：Radiation research

authors： Dallas LJ,Keith-Roach M,Lyons BP,Jha AN

更新日期：2012-05-01 00:00:00

abstract：:To date, there are no safe and effective drugs available for protection against ionizing radiation damage. Therefore, a great need exists to identify and develop non-toxic agents that will be useful as radioprotectors or postirradiation therapies under a variety of operational scenarios. We have developed a new pharma...

journal_title：Radiation research

authors： Singh VK,Ducey EJ,Fatanmi OO,Singh PK,Brown DS,Purmal A,Shakhova VV,Gudkov AV,Feinstein E,Shakhov A

更新日期：2012-05-01 00:00:00

abstract：:Exposure to ionizing radiation or a variety of chemical agents is known to increase the risk of developing malignancy and many tumors have been linked to inflammatory processes. In most studies, the potentially harmful effects of ionizing radiation or other agents are considered in isolation, mainly due to the large n...

journal_title：Radiation research

authors： McAllister KA,Lorimore SA,Wright EG,Coates PJ

更新日期：2012-05-01 00:00:00

abstract：:Technological developments in radiation therapy and other cancer therapies have led to a progressive increase in five-year survival rates over the last few decades. Although acute effects have been largely minimized by both technical advances and medical interventions, late effects remain a concern. Indeed, the need t...

journal_title：Radiation research

authors： Robbins ME,Brunso-Bechtold JK,Peiffer AM,Tsien CI,Bailey JE,Marks LB

更新日期：2012-04-01 00:00:00

abstract：:Molecular imaging is an evolving science that is concerned with the development of novel imaging probes and biomarkers that can be used to non-invasively image molecular and cellular processes. This special issue approaches molecular imaging in the context of radiation research, focusing on biomarkers and imaging meth...

journal_title：Radiation research

authors： Humm JL,Dewhirst MW,Bhujwalla ZM

更新日期：2012-04-01 00:00:00

abstract：:This is the 14th report in a series of periodic general reports on mortality in the Life Span Study (LSS) cohort of atomic bomb survivors followed by the Radiation Effects Research Foundation to investigate the late health effects of the radiation from the atomic bombs. During the period 1950-2003, 58% of the 86,611 L...

journal_title：Radiation research

authors： Ozasa K,Shimizu Y,Suyama A,Kasagi F,Soda M,Grant EJ,Sakata R,Sugiyama H,Kodama K

更新日期：2012-03-01 00:00:00

abstract：:This study investigated the biological effects and adaptive responses induced by single and repeated in vivo computed tomography (CT) scans. We postulated that, through the induction of low-level oxidative stress, repeated low-dose CT scans (20 mGy, 2 days/week, 10 weeks) could protect mice (C57BL/6) from acute effect...

journal_title：Radiation research

authors： Phan N,De Lisio M,Parise G,Boreham DR

更新日期：2012-02-01 00:00:00

abstract：:Fanconi anemia (FA) is an inherited disorder characterized by defective DNA repair and cellular sensitivity to DNA crosslinking agents. Clinically, FA is associated with high risk for marrow failure, leukemia and head and neck squamous cell carcinoma (HNSCC). Radiosensitivity in FA patients compromises the use of tota...

journal_title：Radiation research

authors： Bernard ME,Kim H,Berhane H,Epperly MW,Franicola D,Zhang X,Houghton F,Shields D,Wang H,Bakkenist CJ,Frantz MC,Forbeck EM,Goff JP,Wipf P,Greenberger JS

更新日期：2011-11-01 00:00:00

abstract：:We recently reported that daily dietary supplementation with 100 µg selenium (a dose exceeding a rat's nutritional requirement by about 33-fold) initiated immediately after total-body irradiation (TBI) and maintained for 21 weeks mitigates radiation nephropathy in a rat model as indicated by blood urea nitrogen (BUN) ...

journal_title：Radiation research

authors： Sieber F,Muir SA,Cohen EP,Fish BL,Mäder M,Schock AM,Althouse BJ,Moulder JE

更新日期：2011-09-01 00:00:00